版權所有 ? 北京天廣實生物技術股份有限公司

京ICP備 09113705 號   網站建設:中企動力 北京

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職位詳細

職位名稱:

抗體工程總監/資深總監

薪資:
面議
工作地點:
北京市-北京市-大興區
所屬部門:
前期研發部
招聘人數:
1
工作性質:
全職
工作年限:
5-10年
學歷:
博士
年齡:
性別:
不限
發布時間:
4小時前
瀏覽量:
職位描述:

抗體工程總監/資深總監

Director/Senior Director – Antibody Engineering

職位概述:

Position Summary:

2.1 領導由10多名科學家組成的團隊,致力于抗體工程,治療性抗體發現項目。

Lead and supervise a team of >10 scientists focusing on antibody engineering to support our therapeutic antibody discovery programs.

2.2 負責抗體工程工作的所有工作,包括抗體表達和純化,噬菌體展示文庫的設計和構建,親和力成熟,人源化,Fc工程,雙特異性抗體設計和優化,可藥用性評估和優化。

Oversee all aspects of antibody engineering efforts including antibody expression and purification, phage display library design and construction, affinity maturation, humanization, Fc engineering, bispecific antibody design and optimization, druggability assessment and optimization.

2.3 建立和管理與內外部科學資源的有效合作。

Build and manage productive collaborations with internal and external scientific resources.

2.4 在內部和外部會議上以清晰簡潔的方式記錄、分析、解釋和展示實驗數據。

Document, analyze, interpret and present experimental data in a clear and concise manner in internal and external conferences.

2.5 識別并建立與Mabworks現有技術平臺協同增效的關鍵領域和技術平臺

 Identify and build key areas and technology platforms with synergies to Mabworks’ current technology platforms.

2.6 領導解決所有的技術和科學問題

Lead all efforts in troubleshooting and solving any technical and scientific issues.

2.7 在團隊內建立積極的、團隊合作的、以結果為導向的文化。

Contribute to building a positive, team-oriented and results-oriented culture within the team.

 

任職條件:

Position Qualification:

1、生物化學、免疫學、結構生物學、蛋白質工程或相關學科博士學位,至少5年生物技術/制藥領域研發經驗,或碩士學位,具有10年以上研發經驗。

PhD in biochemistry, immunology, structural biology, protein engineering or a related discipline with at least 5 years of R&D experience in a biotech/pharmaceutical environment or Master’s degree with more than 10 years of R&D experience.

2、在抗體生成和工程、噬菌體展示或其他展示平臺、親和優化、人源化、Fc工程、雙特異性抗體平臺設計和優化、抗體耐藥性評估和優化方面具有豐富的實際經驗。

Extensive hands-on experience in antibody generation and engineering, phage display or other display platforms, affinity optimization, humanization, Fc engineering, bispecific antibody platform design and optimization,  and antibody druggability assessment and optimization as evidenced by a strong publication record, patent applications and pipeline contributions to IND submissions.

3、必須具備較強的結構生物學背景,在抗體結構建模、序列預測方面有全面的知識和實踐經驗,對抗體結構-功能關系有較強的理解

A successful candidate must have strong background in structural biology, comprehensive knowledge and hands-on experiences in antibody structural modeling, sequence prediction, as well as strong understanding of antibody structure-function relationships.

4、熟悉雙特異性抗體支架,有雙特異性抗體分子結構設計/改進的實際經驗者優先

Familiarity with bispecific antibody scaffolds and hands-on experience in BsAb format design/improvement is an asset.

5、有新抗體發現、工程或展示平臺工作經驗者優先

Experience in working on novel antibody discovery, engineering or display platforms is an asset.

6、具備很強的人員管理能力,能夠在團隊合作的環境中工作,具備優秀的溝通和語言表達能力(中英文)。

An ideal candidate must have strong people management skills, ability to work in a team-oriented environment and excellent communication and language skills (Chinese and English). 

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